Observe Intently (one)lumefantrine will lessen the level or result of exemestane by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Check. For clients acquiring exemestane which has a powerful CYP3A4 inducer the suggested dose of exemestane is fifty mg day-to-day after a meal.Aromasin includes the Lively drug exemestane. Arimidex